Designing a multifunctional Ti-2Cu-4Ca porous biomaterial with favorable mechanical properties and high bioactivity

Year: 
2017
Month: 
8
Day: 
18
Pages: 
338-345
DOI: 
10.1016/j.jallcom.2017.08.145
Type: 
Journal Articles
Journal: 
Journal of Alloys and Compounds
Volume: 
727
Abstract: 

The appropriate combination between bones and implants is an important issue for the long-term stability of biomaterials. Hence, a Ti implant alloy with stable osteointegration and simultaneously
low modulus is extremely desirable. Ca possesses superb bioactivity and biodegradability in orthopedic applications. Cu is not only favorable for angiogenesis but also exhibits prolonged antibacterial effects. In our present work, Cu and Ca are thus selected as alloying elements to develop a multifunctional Ti-2Cu-4Ca biomaterial with controllable pore structure through spark plasma sintering (SPS). The developed porous Ti-2Cu-4Ca alloy with interconnected pores, a porosity of 43% ± 5% and an average pore size of 460 mm, exhibits bone-like mechanical properties and enhanced cellular affinity (ROS1728 cells). The favorable cell viability and growth inside the pores of the alloy arise from the rough porous surface and the release of bioactive Ca and Cu ions into the biological environment. Our work provides a strategy to design multifunctional biomaterials and, specifically, the porous Ti-2Cu-4Ca alloy is expected to be a promising bone-implant biomaterial.